Description

Methylmalonyl-Coenzyme A is a crucial biochemical intermediate in metabolic pathways, particularly in the catabolism of branched-chain amino acids, odd-chain fatty acids, and cholesterol. Its primary value lies in its role as a substrate for the enzyme methylmalonyl-CoA mutase, making it essential for research into inborn errors of metabolism like methylmalonic acidemia. This high-purity biochemical is primarily needed by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in metabolic disorder studies, enzyme kinetics research, and the development of diagnostic assays.

Application

• Biochemical Research: Used as a critical substrate in enzymatic studies, particularly for methylmalonyl-CoA mutase, to understand reaction mechanisms and kinetics.
• Metabolic Disorder Diagnostics: Serves as a standard or reagent in the development and validation of diagnostic tests for methylmalonic acidemia and other related organic acidemias.
• Pharmaceutical Development: Employed in drug discovery programs targeting metabolic pathways, especially for conditions involving propionate metabolism.
• Enzyme Activity Assays: Essential for in vitro assays designed to measure the activity of methylmalonyl-CoA mutase in tissue samples or recombinant enzymes.
• Nutritional & Metabolic Studies: Utilized in research investigating vitamin B12 (cobalamin) deficiency and its impact on methylmalonyl-CoA metabolism.
• Teaching & Reference Standard: Acts as a high-purity reference compound in academic settings and for calibrating analytical equipment like HPLC or LC-MS systems.

Basic Information

Product Name	Methylmalonyl-Coenzyme A
CAS No.	1264-45-5
Molecular Formula	C₂₅H₄₂N₇O₁₉P₃S
Molecular Weight	853.64 g/mol
Synonyms	Methylmalonyl-CoA; (2R)-2-Methyl-3-oxopropanoyl-CoA; S-[2-[3-[[(2R)-2-[[[5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutoxy]hydroxyphosphoryl]oxyethyl] (2R)-2-methyl-3-oxopropanethioate; Methylmalonyl Coenzyme A; Coenzyme A, methylmalonyl-; MM-CoA
EINECS	215-024-8

Quality Control

Our Methylmalonyl-Coenzyme A is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant quality management standards to guarantee the integrity of our biochemical products for the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term stability, store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	≥ 90% (Enzymatic assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.