Description

[6R-[6alpha,7beta(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, compound with propane-1,2-diol is a high-purity pharmaceutical intermediate and a derivative of a cephalosporin antibiotic. This compound is critical for the research and development of novel antibacterial agents, particularly in the synthesis of advanced β-lactam antibiotics. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers focused on developing next-generation therapeutics to combat resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced cephalosporin-class antibiotics.
• Antibacterial Research: Used in R&D for developing new antibacterial agents with modified side chains to improve efficacy and spectrum of activity.
• Fine Chemical Synthesis: Serves as a precursor for creating specialized chemical entities in medicinal chemistry.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Studies: Employed in studies investigating the structure-activity relationships (SAR) of β-lactam antibiotics and their interaction with bacterial enzymes.

Basic Information

Item	Details
Product Name	[6R-[6alpha,7beta(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, compound with propane-1,2-diol
CAS No.	57235-40-2
Molecular Formula	C20H22N6O6S2 • C3H8O2
Molecular Weight	Contact for details
Synonyms	Cefamandole Propylene Glycol Adduct; Cefamandole Nafate Related Compound; (6R,7R)-7-[(R)-2-Amino-2-(4-hydroxyphenyl)acetamido]-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid compound with 1,2-Propanediol; Mandol Related Compound; Cefamandole (propylene glycol solvate); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivative with propane-1,2-diol
EINECS	Contact for details

Quality Control

Our [6R-[6alpha,7beta(R*)]]-7-[[amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, compound with propane-1,2-diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Recommended storage temperature is between 2°C and 8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) may be acceptable. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.