Description

5,6,11,12-Tetrahydro-3,8,9-trimethoxy-13-methyl-1-[[(6aS)-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-9-yl]oxy]-5α,11α-epiminodibenzo[a,e]cycloocten-4-ol is a complex, high-purity alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and study of novel bioactive molecules targeting the central nervous system. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in medicinal chemistry and pharmacology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex alkaloid-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity calibration standard in analytical method development and quality control for drug substances.
• Medicinal Chemistry Research: Core scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Neuroscience Research: Investigated for its potential interaction with specific neurotransmitter receptors and ion channels.
• Process Development: Serves as a model compound for optimizing synthetic routes and purification processes in pilot-scale manufacturing.

Basic Information

Product Name	5,6,11,12-Tetrahydro-3,8,9-trimethoxy-13-methyl-1-[[(6aS)-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-9-yl]oxy]-5α,11α-epiminodibenzo[a,e]cycloocten-4-ol
CAS No.	53416-82-3
Molecular Formula	C41H46N2O8
Molecular Weight	694.82 g/mol
Synonyms	13-Methylberbine derivative; Tetrahydroprotoberberine alkaloid; Corydaline related compound; 5α,11α-Epiminodibenzo[a,e]cyclooctenol derivative; (6aS)-1,2,10-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-9-yl ether; Isoquinoline alkaloid intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical-grade material is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.