Description

Seneciphylline is a pyrrolizidine alkaloid of significant interest in pharmaceutical and biochemical research. This compound serves as a critical reference standard and intermediate for the development of analytical methods and toxicological studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and quality control laboratories focused on natural product chemistry and safety assessment.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantification and identification of pyrrolizidine alkaloids in herbal medicines and dietary supplements.
• Biochemical Research: Employed in studies investigating the metabolism, hepatotoxicity, and mechanism of action of pyrrolizidine alkaloids.
• Analytical Method Development: Serves as a key calibrant in developing and validating analytical methods such as HPLC, LC-MS, and GC-MS for contaminant screening.
• Toxicology and Safety Assessment: Used as a standard in toxicological assays to establish safety profiles and regulatory limits for herbal ingredients.
• Natural Product Isolation & Synthesis: Acts as a marker compound in the isolation of plant extracts and as an intermediate in synthetic chemistry studies.

Basic Information

Product Name	Seneciphylline
CAS No.	480-81-9
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	Senecifolin; 12,18-Didehydrosenecionan-11,16-dione, 13,19-didehydro-12-hydroxy-; (13Z)-Senecionan-11,16-dione, 12,18-didehydro-12-hydroxy-; NSC 32917; Pyrrolizidine alkaloid (Seneciphylline); Retrorsine N-oxide (related); Alkaloid from Senecio species.
EINECS	Contact for details

Quality Control

Our Seneciphylline is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, analytical methods, and batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.