Description

(-)-β-Hydrastine CAS NO 118-08-1 is a naturally occurring isoquinoline alkaloid, recognized for its distinct stereochemistry and biological activity. This compound is of significant interest in pharmaceutical research and development due to its potential as a biochemical tool and a reference standard. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in phytochemical analysis, drug discovery, and quality control of botanical extracts.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the identification and quantification of hydrastine in pharmaceutical products and herbal supplements.
• Biochemical Research: Serves as a key intermediate or active compound in pharmacological studies investigating its effects on smooth muscle and neurotransmitter systems.
• Natural Product Isolation: Employed as a marker compound in the extraction, purification, and standardization of botanical ingredients, particularly from *Hydrastis canadensis* (Goldenseal).
• Analytical Method Development: Essential for developing and validating chromatographic methods (HPLC, LC-MS) for the analysis of alkaloid-containing samples.
• Academic & Educational Use: Provided to universities and research centers for teaching and advanced studies in organic chemistry and pharmacognosy.

Basic Information

Product Name	(-)-β-Hydrastine
CAS No.	118-08-1
Molecular Formula	C21H21NO6
Molecular Weight	383.40 g/mol
Synonyms	(-)-β-Hydrastine; β-Hydrastine; Hydrastine; (3S,3'S,5'R,6S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-5'H-[1,3']bipyridinyl-3,5',6'-trione; 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-; Natural Hydrastine
EINECS	204-231-8

Quality Control

Our (-)-β-Hydrastine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and reference materials. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for that lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	-50° to -55° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.