Description

(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester is a sophisticated, high-purity chemical intermediate of significant importance in advanced pharmaceutical synthesis. This compound is a key building block in the development of novel β-lactam antibiotics and other complex therapeutic agents, offering researchers a reliable and well-characterized starting material. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of next-generation antibacterial drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel carbapenem and penem class antibiotics.
• Antibacterial Drug Research: Serves as a key scaffold for medicinal chemists exploring new structures with activity against resistant bacterial strains.
• Process Chemistry Development: Used in the optimization and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of β-lactam compounds and their interaction with bacterial enzymes.
• Fine Chemical Synthesis: A valuable chiral building block for constructing complex molecules with multiple stereocenters.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
CAS No.	491878-07-0
Molecular Formula	C30H33N5O11S2
Molecular Weight	703.74 g/mol
Synonyms	PNZ-PNB Ester Intermediate; (4-Nitrophenyl)methyl (4R,5S,6S)-3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; Carbapenem Derivative PNZ-PNB Ester; 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid intermediate; β-lactam synthesis intermediate; CAS 491878-07-0
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is produced under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Specifications are controlled via advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.