Description

(6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide is a complex, high-value synthetic intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for advanced organic synthesis, particularly in constructing intricate molecular architectures found in active pharmaceutical ingredients. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, where precise stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of complex drug candidates, especially in oncology and metabolic disease research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with improved efficacy and selectivity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, aiding in the development of robust and cost-effective manufacturing processes.
• Asymmetric Synthesis: Utilized in reactions requiring high enantiomeric purity, leveraging its defined stereocenters to induce chirality in subsequent reaction steps.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement, due to its potential for further functionalization.

Basic Information

Product Name	(6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide
CAS No.	344798-32-9
Molecular Formula	C30H47IO3SSi
Molecular Weight	642.74 g/mol
Synonyms	(6S)-6-[(tert-Butyldimethylsilyl)oxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]methyl]-2,1-benzothiazole 2,2-dioxide; (6S)-6-(tert-Butyldimethylsiloxy)-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]methyl]benzo[c]thiophene 2,2-dioxide; TBS-protected iodoindenyl benzothiophene sulfone derivative; CAS 344798-32-9.
EINECS	Contact for details

Quality Control

Our (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The container should be kept in a dry, well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.