Description

15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,3-[(1E)-2-[(1R,3R,4R)-3,4-dihydroxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- is a complex, high-purity macrolide compound of significant interest in advanced pharmaceutical research and development. Its intricate stereochemistry and functional groups make it a valuable intermediate or reference standard for the synthesis and study of novel bioactive molecules. This product is essential for R&D laboratories and pharmaceutical manufacturers focused on antibiotic discovery, chemical biology, and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel macrolide antibiotics and other complex therapeutic agents.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories to ensure product identity and purity.
• Medicinal Chemistry Research: A critical tool for structure-activity relationship (SAR) studies to explore and optimize biological activity profiles.
• Chemical Biology Probes: Utilized in biochemical and cellular assays to investigate specific biological pathways and target interactions.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Academic Research: Supports fundamental studies in organic synthesis, natural product chemistry, and pharmacology at universities and research institutes.

Basic Information

Item	Details
Product Name	15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,3-[(1E)-2-[(1R,3R,4R)-3,4-dihydroxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
CAS No.	127984-76-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FK-506 Related Compound; Tacrolimus Related Compound; FR-900520; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[(1E)-2-[(1R,3R,4R)-3,4-dihydroxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; Ascomycin derivative; 26a-demethoxy-26a-oxo-FK506; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[2-[(1R,3R,4R)-3,4-dihydroxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*,4R*,5S*,8R*,9E,12S*,14S*,15R*,16S*,18R*,19R*,26aS*]]-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and MS to verify identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Our quality management system is designed to support GMP-grade applications and research requiring high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated area. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.