Description

(2S,3S,5R)-N-(3-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)PROPYL)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE is a sophisticated, multi-functional nucleoside analog derivative designed for advanced pharmaceutical research and development. This compound is of significant interest due to its complex structure, which incorporates multiple azido groups and a thymine base analog, making it a valuable building block for prodrug synthesis and targeted drug delivery systems. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel antiviral and anticancer therapeutics, where precise molecular architecture is critical for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel nucleoside-based antiviral and anticancer agents.
• Prodrug Development: The presence of multiple azido groups allows for bio-orthogonal click chemistry, enabling the construction of targeted prodrugs and antibody-drug conjugates (ADCs).
• Bioconjugation & Labeling: Used in chemical biology for labeling biomolecules (proteins, oligonucleotides) via azide-alkyne cycloaddition reactions.
• Medicinal Chemistry Research: A critical tool for structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of new drug candidates.
• Antiviral Agent Synthesis: Investigated as a core scaffold for compounds targeting viral polymerases and reverse transcriptases.
• Chemical Probe Synthesis: Employed to create molecular probes for studying cellular processes and enzyme functions.

Basic Information

Item	Details
Product Name	(2S,3S,5R)-N-(3-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)PROPYL)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE
CAS No.	948916-27-6
Molecular Formula	C26H38N14O11
Molecular Weight	698.67 g/mol
Synonyms	3'-Azido-3'-deoxythymidine (AZT) Triazido Derivative; Multi-Azido Nucleoside Analog; 5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl Tetrahydrofuran Carboxamide Derivative; Azido-Modified Thymidine Intermediate; Click Chemistry Nucleoside Building Block; Prodrug Intermediate 948916-27-6; CAS 948916-27-6
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity required for sensitive pharmaceutical research. Our quality system includes comprehensive analytical characterization using HPLC, NMR, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. Production can be aligned with cGMP guidelines for advanced preclinical and clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.