Description

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl ester N-[(2',7'-difluoro-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine is a sophisticated, high-purity chemical intermediate designed for advanced research and development. This compound is critical for its role in the synthesis and study of complex molecular structures, particularly in pharmaceutical discovery. It is essential for researchers and process chemists in the life sciences sector who require precise and reliable building blocks for developing novel therapeutic agents and diagnostic probes.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of novel drug candidates, particularly for targeted therapies.
• Fluorescent Probe Synthesis: Used to create advanced fluorescent conjugates and labels for bioimaging and diagnostic assays, leveraging the integrated xanthene fluorophore moiety.
• Chemical Biology Studies: Serves as a specialized tool compound for investigating enzyme mechanisms, protein interactions, and cellular pathways.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for complex active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for cutting-edge organic chemistry and medicinal chemistry projects.
• Diagnostic Reagent Manufacturing: Acts as a precursor for high-sensitivity reagents used in clinical diagnostics and life science research kits.

Basic Information

Product Name	(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl ester N-[(2',7'-difluoro-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine
CAS No.	301844-13-3
Molecular Formula	C71H65FN2O19
Molecular Weight	1268.28 g/mol
Synonyms	Oregon Green 488 Taxol Conjugate; Oregon Green 488-Paclitaxel Conjugate; 5-FAM-Paclitaxel; Fluorescein-Paclitaxel Conjugate (Oregon Green 488 variant); N-[(2',7'-Difluoro-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanyl paclitaxel ester; Paclitaxel, Oregon Green™ 488 conjugate; Taxol, Oregon Green® 488 conjugate; CAS 301844-13-3
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for sensitive research applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. Quality management adheres to cGMP principles where applicable to support pharmaceutical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Store under inert atmosphere if specified.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in acetonitrile, methanol
Fluorescence Properties	Excitation/Emission maxima consistent with Oregon Green 488 dye

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.