Description

1H-Isoindol-1-one, 6-[(1S)-1-[(3S)-3-fluoro-1-pyrrolidinyl]ethyl]-2,3-dihydro-2-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-4-(trifluoromethyl)- is a sophisticated chiral organic compound featuring a complex molecular architecture with multiple heterocyclic and fluorinated motifs. This compound is of significant interest for its potential as a high-value pharmaceutical intermediate or active pharmaceutical ingredient (API) building block, particularly in the development of targeted therapeutics. It is primarily sought by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a key scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Potential application as a component of bifunctional molecules designed for targeted protein degradation.
• Kinase Inhibitor Synthesis: The structural features suggest utility in the development of selective kinase inhibitors.
• Chemical Biology Probes: Employed in the creation of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP or non-GMP production campaigns.

Basic Information

Product Name	1H-Isoindol-1-one, 6-[(1S)-1-[(3S)-3-fluoro-1-pyrrolidinyl]ethyl]-2,3-dihydro-2-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-4-(trifluoromethyl)-
CAS No.	2368840-65-5
Molecular Formula	C30H30F4N6O2
Molecular Weight	558.60 g/mol
Synonyms	6-[(1S)-1-[(3S)-3-fluoro-1-pyrrolidinyl]ethyl]-2,3-dihydro-2-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-4-(trifluoromethyl)-1H-isoindol-1-one; (S)-6-(1-((S)-3-fluoropyrrolidin-1-yl)ethyl)-2-(3-(3-((4-methyl-4H-1,2,4-triazol-3-yl)methyl)oxetan-3-yl)phenyl)-4-(trifluoromethyl)isoindolin-1-one; CAS 2368840-65-5; 1H-Isoindol-1-one derivative with trifluoromethyl and triazole groups; Fluorinated isoindolinone-triazole-oxetane conjugate.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and LC-MS for identity confirmation and purity assessment. Certificates of Analysis (COA) detailing batch-specific results are available upon request. For cGMP-grade material, production and control follow ICH Q7 guidelines, and regulatory support documentation (DMF) can be provided under confidentiality agreement.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. Keep the container in a dry, well-ventilated area. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Standard Grade) ≥ 98.0% (High Purity Grade)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.