17,?19-?Metheno-?1H,?5H-?cyclopent[5,?6]?[1,?4]?oxazino[3,?4-?i]?pyrazolo[4,?3-?f]?pyrido[3,?2-?l]?[1,?4,?8,?10]?oxatriazacyclotridec?in-?14(11H)?-?one, 7-?fluoro-?2,?3,?3a,?12,?13,?20a-?hexahydro-?11-?methyl-?, (3aR,?11S,?20aS)?- CAS NO 2359649-81-1

Unit Price:

CAS No.:2359649-81-1

Grade:Pharmacy Grade

Content:99.9%

Brand:Customizable

Packaging:Customizable

Description

17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aR,11S,20aS)- is a complex, high-purity heterocyclic organic compound with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate. Its intricate polycyclic structure, featuring fused oxazine, pyrazole, pyrido, and oxatriazacyclotridecin rings, makes it a valuable building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug research.

Application

Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for targeted cancer therapies.
Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
API Synthesis: Employed in the multi-step synthesis of complex final Active Pharmaceutical Ingredients (APIs) requiring high stereochemical purity.
Biochemical Research: Potential use as a tool compound or probe for investigating specific biological pathways and enzyme interactions in vitro.
Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.

Basic Information


Product Name	17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aR,11S,20aS)-
CAS No.	2359649-81-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(3aR,11S,20aS)-7-Fluoro-11-methyl-2,3,3a,12,13,20a-hexahydro-17,19-metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one; CAS 2359649-81-1; 7-Fluoro-11-methyl-hexahydro-17,19-metheno-cyclopent[5,6]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14-one; Advanced Pharmaceutical Intermediate 2359649-81-1; Fluorinated Polycyclic Heterocycle; Complex Fused Ring System Intermediate.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development under non-GMP conditions, with the capability to supply cGMP-grade material for advanced clinical applications. Quality is verified through advanced analytical techniques including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for every batch.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. For long-term storage, consider storing under an inert atmosphere in a cool, dry place. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Typical: ≥97%)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<20 ppm