Description

1H-1,2,3-Triazole-4-carboxamide, 1-(1,1-dimethylethyl)-N-[(5R)-2,3,4,5-tetrahydro-8-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-2-(3-oxetanyl)-1H-2-benzazepin-5-yl]- is a sophisticated heterocyclic compound designed for advanced pharmaceutical research and development. This high-purity intermediate is critical for medicinal chemists exploring novel therapeutic pathways, particularly in targeted drug discovery. It serves as a key building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The molecular structure suggests potential utility in the design and synthesis of novel kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Serves as a starting material for creating specialized probes to study biological pathways and target engagement.
• Process Chemistry & Scale-up: Supports route scouting and process development for the efficient, scalable production of candidate drugs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical innovation pipelines.

Basic Information

Product Name	1H-1,2,3-Triazole-4-carboxamide, 1-(1,1-dimethylethyl)-N-[(5R)-2,3,4,5-tetrahydro-8-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-2-(3-oxetanyl)-1H-2-benzazepin-5-yl]-
CAS No.	2247614-80-6
Molecular Formula	C28H35N9O2
Molecular Weight	529.64 g/mol
Synonyms	1-(tert-Butyl)-N-[(5R)-8-[2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl]-1H-1,2,3-triazole-4-carboxamide; (5R)-5-[[1-(tert-Butyl)-1H-1,2,3-triazole-4-carbonyl]amino]-8-[2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-2-benzazepine; CAS 2247614-80-6; tert-Butyl triazole carboxamide benzazepine derivative; Advanced kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our 1H-1,2,3-Triazole-4-carboxamide derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable for pharmaceutical intermediates, and our analytical methods are validated to meet the stringent requirements of advanced R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. This compound is likely hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability. Keep container tightly sealed in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.