Description

1H-Pyrrole-1,2-dicarboxylic acid, 3-amino-4-(3aS,4S,6R,6aR)-5-(1,1-dimethylethoxy)carbonyltetrahydro-6-(hydroxymethyl)-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-, 2-ethyl 1-(phenylmethyl) ester is a sophisticated, high-purity chemical intermediate characterized by its complex, multi-functional molecular architecture. This compound is of significant value for its role as a key building block in advanced organic synthesis, particularly in the construction of complex pharmacologically active molecules. It is primarily sought after by research institutions and pharmaceutical development teams engaged in the synthesis of novel active pharmaceutical ingredients (APIs), nucleoside analogs, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex nucleoside-based drugs and other high-value APIs.
• Antiviral Drug Research: Serves as a key scaffold in the development of novel antiviral compounds, including potential treatments for viral infections.
• Nucleoside Chemistry: Used in the preparation of modified nucleosides and nucleotides for biochemical and therapeutic applications.
• Medicinal Chemistry & Lead Optimization: Employed in research labs for structure-activity relationship (SAR) studies and the optimization of drug candidates.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Bioconjugation & Probe Synthesis: The reactive functional groups make it suitable for creating labeled compounds for diagnostic or research purposes.

Basic Information

Item	Details
Product Name	1H-Pyrrole-1,2-dicarboxylic acid, 3-amino-4-(3aS,4S,6R,6aR)-5-(1,1-dimethylethoxy)carbonyltetrahydro-6-(hydroxymethyl)-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-, 2-ethyl 1-(phenylmethyl) ester
CAS No.	284490-17-1
Molecular Formula	C27H35N3O9
Molecular Weight	545.59 g/mol
Synonyms	3-Amino-4-[(3aS,4S,6R,6aR)-5-[(tert-butoxy)carbonyl]-6-(hydroxymethyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-1H-pyrrole-1,2-dicarboxylic acid 2-ethyl 1-benzyl ester; Benzyl 2-ethyl 3-amino-4-[(3aS,4S,6R,6aR)-5-(tert-butoxycarbonyl)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-1H-pyrrole-1,2-dicarboxylate; 1-Benzyl 2-ethyl 3-amino-4-[(3aS,4S,6R,6aR)-5-(tert-butoxycarbonyl)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-1H-pyrrole-1,2-dicarboxylate; Advanced nucleoside intermediate; Protected pyrrole-dicarboxylate ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. Quality is verified through a battery of analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.