Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1Z)-1-cyano-2-hydroxyethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, stereospecific active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial research for constructing novel heterocyclic compounds and exploring new chemical spaces.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Medicinal Chemistry: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs, particularly for targets involving complex molecular scaffolds.
• Custom Synthesis: Supplied for bespoke manufacturing projects requiring high-purity, specialty intermediates with protected functional groups.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1Z)-1-cyano-2-hydroxyethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	284490-14-8
Molecular Formula	C22H34N2O6Si
Molecular Weight	450.61 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-[(1Z)-1-Cyano-2-hydroxyethenyl]-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3aS,4S,6R,6aR)-4-((Z)-1-cyano-2-hydroxyvinyl)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; TBDMS-protected pyrrole-dioxolane intermediate; CAS 284490-14-8.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support our partners in pharmaceutical development with the documentation required for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.