Description

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone is a sophisticated chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of high-value, optically pure compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for CNS and anti-infective applications.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective organic synthesis to construct complex molecular architectures.
• API Development: Serves as a critical building block in the multi-step synthesis of target active pharmaceutical ingredients (APIs).
• Process Chemistry: Employed in route scouting and scale-up optimization for the commercial manufacturing of pharmaceuticals.
• Academic & Contract Research: Utilized in university and CRO settings for methodological studies in synthetic organic and medicinal chemistry.
• Custom Synthesis: A starting material for the preparation of more complex, proprietary derivatives for specialized client projects.

Basic Information

Product Name	3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone
CAS No.	272778-12-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(4S)-4-Phenyl-3-[(2R,5S)-5-(4-fluorophenyl)-2-[[(S)-(4-fluorophenyl)(amino)][4-(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-1,3-oxazolidin-2-one; Fluorophenyl-trimethylsilyl oxy oxazolidinone derivative; Chiral oxazolidinone building block; Advanced fluorinated pharmaceutical intermediate; CAS 272778-12-8.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets the stringent requirements for pharmaceutical R&D and process development. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request. Our quality system is designed to support cGMP and ISO guidelines for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.