Description

Carbamic acid, 4-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-ylphenylmethyl-, 1,1-dimethylethyl ester is a sophisticated, high-purity chemical intermediate featuring a protected nucleoside-like structure. This compound matters for its role as a critical building block in the synthesis of complex pharmaceutical agents, particularly antiviral and anticancer nucleoside analogs. It is primarily needed by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in advanced drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel nucleoside-based therapeutics.
• Antiviral Drug Development: Used in research and production of potential antiviral agents targeting viral polymerases.
• Anticancer Agent Synthesis: Serves as a precursor for the development of nucleoside analogs with anticancer activity.
• ProTide Technology: Applicable in the synthesis of ProTide prodrugs to enhance the bioavailability and efficacy of nucleotide analogs.
• Organic Synthesis Research: A valuable reagent for academic and industrial research in stereoselective synthesis and heterocyclic chemistry.
• Process Chemistry: Employed in the scale-up and optimization of manufacturing routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Carbamic acid, 4-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-ylphenylmethyl-, 1,1-dimethylethyl ester
CAS No.	258834-85-4
Molecular Formula	C28H46N2O6Si
Molecular Weight	534.77 g/mol
Synonyms	tert-Butyl N-[[4-[(3aS,4S,6R,6aR)-6-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-3a,4,6,6a-tetrahydro-1,3-dioxolo[4,5-c]pyrrol-4-yl]phenyl]methyl]carbamate; 4-[(3aS,4S,6R,6aR)-6-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]benzenemethanol, N-[(1,1-dimethylethoxy)carbonyl] derivative; TBDMS-protected nucleoside carbamate intermediate; (3aS,4S,6R,6aR)-4-[4-[[(tert-Butoxycarbonyl)amino]methyl]phenyl]-6-[[(tert-butyldimethylsilyl)oxy]methyl]-2,2-dimethyl-tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole; BOC-Amino-TBDMS-Nucleoside Derivative
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.