Description

Carbamic acid, 4-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-1-naphthalenyl-, 1,1-dimethylethyl ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined structure. This compound is critical for ensuring the precise synthesis and consistent quality of target active pharmaceutical ingredients (APIs), particularly in complex therapeutic areas. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of sophisticated small-molecule drugs.

Application

• Key Intermediate in Nucleoside/Nucleotide Analog Synthesis: Serves as a crucial building block for the production of novel antiviral and anticancer agents.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the exploration and optimization of new drug candidates with specific stereochemical requirements.
• Process Chemistry & Scale-Up: Employed in the development of robust and scalable synthetic routes for GMP manufacturing.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs producing APIs for clinical trials and commercial supply under strict quality agreements.
• Synthesis of Prodrugs: Utilized in the design of prodrugs to enhance the bioavailability or targeting of therapeutic molecules.

Basic Information

Product Name	Carbamic acid, 4-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-1-naphthalenyl-, 1,1-dimethylethyl ester
CAS No.	258834-84-3
Molecular Formula	C30H45NO6Si
Molecular Weight	543.78 g/mol
Synonyms	tert-Butyl (4-((3aS,4S,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl)naphthalen-1-yl)carbamate; 1-Naphthalenecarbamic acid, 4-((3aS,4S,6R,6aR)-6-(((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydro-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl)-, 1,1-dimethylethyl ester; TBDMS-protected nucleoside intermediate; Advanced carbamate-protected pyrrolidine intermediate; Stereoisomeric pharmaceutical building block
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, with in-process controls and final release testing to ensure batch-to-batch consistency. Quality is verified against comprehensive specifications, including chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation (NMR, MS). A detailed Certificate of Analysis (COA) is provided with each shipment, and we support audits and the submission of Drug Master File (DMF) sections as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.