Description

1,3,5,2,4-Trioxadisilocino7,6-bpyrrole-7(6H)-carboxylic acid, 8-(cyanomethyl)tetrahydro-9-hydroxy-2,2,4,4-tetrakis(1-methylethyl)-, 1,1-dimethylethyl ester, (6aR,8S,9S,9aR)- is a high-purity, stereochemically defined advanced intermediate with a complex heterocyclic structure incorporating silicon and oxygen. This compound is valued for its role as a critical building block in the synthesis of novel materials and active pharmaceutical ingredients (APIs), where its unique architecture enables precise molecular design. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating next-generation products with specific functional properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the creation of advanced crop protection agents and pesticides, leveraging its structural complexity for enhanced biological activity.
• Material Science Research: Serves as a precursor for developing novel silicon-oxygen containing polymers or hybrid organic-inorganic materials with tailored properties.
• Organic Electronics: Investigated as a potential component in the synthesis of specialty chemicals for electronic applications due to its specific molecular architecture.
• Chemical Biology Probes: Utilized in academic and industrial research to create molecular probes for studying biological systems and enzyme mechanisms.
• Catalyst Ligand Development: The sterically hindered and functionalized structure makes it a candidate for developing novel ligands in asymmetric catalysis.

Basic Information

Product Name	1,3,5,2,4-Trioxadisilocino7,6-bpyrrole-7(6H)-carboxylic acid, 8-(cyanomethyl)tetrahydro-9-hydroxy-2,2,4,4-tetrakis(1-methylethyl)-, 1,1-dimethylethyl ester, (6aR,8S,9S,9aR)-
CAS No.	222854-81-1
Molecular Formula	C26H45NO7Si2
Molecular Weight	539.82 g/mol
Synonyms	tert-Butyl (6aR,8S,9S,9aR)-8-(cyanomethyl)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-1H,3H,5H-[1,3,5,2,4]trioxadisilocino[7,6-b]pyrrole-7(6H)-carboxylate; (6aR,8S,9S,9aR)-1,1-Dimethylethyl 8-(cyanomethyl)tetrahydro-9-hydroxy-2,2,4,4-tetrakis(1-methylethyl)-1,3,5,2,4-trioxadisilocino[7,6-b]pyrrole-7(6H)-carboxylate; Advanced Siloxane-Pyrrole Intermediate; CAS 222854-81-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development and regulatory needs with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.