Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethyisilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and complex organic syntheses.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, target-specific active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Valuable precursor for academic and industrial research in developing new heterocyclic compounds and exploring novel reaction pathways.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot and commercial production.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized, high-value compounds.

Basic Information

Item	Information
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(cyanomethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethyisilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	222631-45-0
Molecular Formula	C24H37N3O5Si
Molecular Weight	475.66 g/mol
Synonyms	tert-Butyl (3aS,4S,6R,6aR)-4-[(1Z)-1-cyano-2-[(cyanomethyl)amino]ethenyl]-6-[[(tert-butyldimethylsilyl)oxy]methyl]-2,2-dimethyl-tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; (3aS,4S,6R,6aR)-tert-Butyl 4-((Z)-1-cyano-2-((cyanomethyl)amino)vinyl)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; CAS 222631-45-0; Advanced Pyrrole-Dioxolane Intermediate; Silyl-Protected Pyrrole Ester.
EINECS	Contact for details

Quality Control

Our 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid tert-butyl ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines for pharmaceutical intermediates, and specifications can be aligned with client requirements for research or regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.