Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(2-ethoxy-2-oxoethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a sophisticated, high-purity synthetic intermediate characterized by its complex, stereochemically defined molecular architecture. This compound is of significant value in advanced organic synthesis, particularly for constructing novel, biologically active molecules where precise stereochemistry and functional group compatibility are critical. It is primarily sought after by research institutions and pharmaceutical development teams engaged in the synthesis of complex heterocycles, nucleoside analogs, and potential therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of novel active pharmaceutical ingredients (APIs), especially for antiviral, anticancer, or neurological drug candidates.
• Nucleoside/Nucleotide Chemistry: Used in the synthesis of modified nucleosides and nucleotides, which are crucial for developing antiviral therapies and molecular biology tools.
• Advanced Organic Synthesis: Serves as a versatile chiral synthon for constructing complex, polyfunctionalized heterocyclic frameworks in academic and industrial research settings.
• Proteolysis-Targeting Chimera (PROTAC) Development: Potential use as a component in linker or warhead chemistry for designing targeted protein degradation molecules.
• Agrochemical Research: May be utilized in the synthesis of novel, high-specificity pesticides or herbicides that require complex, stereospecific structures.
• Material Science Precursor: Can be investigated for creating specialized organic molecules with potential applications in organic electronics or advanced polymers.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-1-cyano-2-(2-ethoxy-2-oxoethyl)aminoethenyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	222631-11-0
Molecular Formula	C27H43N3O7Si
Molecular Weight	549.74 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-(1-Cyano-2-((2-ethoxy-2-oxoethyl)amino)vinyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydro-2,2-dimethyl-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aS,4S,6R,6aR)-4-(1-cyano-2-((2-ethoxy-2-oxoethyl)amino)vinyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; 5H-[1,3]Dioxolo[4,5-c]pyrrole-5-carboxylic acid, 4-[1-cyano-2-[(2-ethoxy-2-oxoethyl)amino]ethenyl]tetrahydro-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-; TBDMS-protected nucleoside intermediate; Advanced chiral pyrrolidine-dioxolane intermediate.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity essential for sensitive synthetic pathways. Our standard offering meets research-grade specifications, with Certificates of Analysis (COA) provided for each lot, detailing purity, identity, and chiral integrity. We adhere to cGMP principles where applicable for production, ensuring traceability and documentation suitable for pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.