Description

Biotinyl-pTH (1-34) (human) trifluoroacetate salt is a synthetic, biotinylated fragment of the human parathyroid hormone (PTH) encompassing amino acid residues 1-34. This modification is critical for research applications, as the biotin tag enables highly sensitive detection, purification, and binding studies of the PTH receptor. It is an essential tool for scientists in endocrinology, bone metabolism research, and drug discovery programs targeting calcium homeostasis disorders. The product is supplied as the trifluoroacetate salt to ensure stability and solubility for experimental use.

Application

• Receptor Binding Assays: Used as a labeled ligand in competitive binding studies to characterize the PTH1 receptor (PTH1R) affinity and kinetics.
• Biosensor Development: Employed in surface plasmon resonance (SPR) and other label-free detection systems to study real-time molecular interactions.
• Pull-Down & Affinity Purification: Facilitates the isolation and identification of PTH receptor complexes from cell lysates using streptavidin-conjugated beads.
• Immunoassay Development: Serves as a standard or tracer in the development of ELISA and other immunoassays for PTH-related research.
• Cell Signaling Research: Applied in studies investigating the cAMP-mediated signaling pathways activated by PTH in osteoblasts and renal cells.
• High-Throughput Screening (HTS): Utilized as a key reagent in screening campaigns for identifying PTH receptor agonists or antagonists.

Basic Information

Product Name	Biotinyl-pTH (1-34) (human) trifluoroacetate salt
CAS No.	213779-14-7
Molecular Formula	C185H294N56O55S2 • xC2HF3O2
Molecular Weight	~4109.6 g/mol (free base)
Synonyms	Biotinylated Parathyroid Hormone (1-34), human; Biotin-PTH (1-34); Biotinyl-hPTH(1-34); Biotinylated PTH Fragment 1-34; PTH (1-34) Biotin Conjugate; Biotin-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH TFA salt
EINECS	Contact for details

Quality Control

Our Biotinyl-pTH (1-34) (human) trifluoroacetate salt is manufactured under controlled conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing. Certificates of Analysis (COA) are provided, detailing specifications for purity, identity, and peptide content. Our quality system supports research requiring reliable and reproducible biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions should be prepared in appropriate buffers and stored in aliquots at -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Complies with theoretical composition
Mass Spectrometry (MS)	Consistent with theoretical molecular weight
Solubility	Soluble in water or aqueous buffer
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.