Description

n-Acetyl-Phe-Octreotide is a synthetic peptide derivative of the therapeutic agent octreotide, modified with an N-terminal acetylation and a phenylalanine substitution. This modification is critical for enhancing metabolic stability and fine-tuning receptor binding affinity for research and development purposes. It serves as a valuable intermediate and reference standard for pharmaceutical scientists and researchers developing novel somatostatin analogs for diagnostic and therapeutic applications, particularly in oncology and endocrinology.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathway for novel octreotide analogs and peptide therapeutics.
• Research & Development: Used as a reference standard in bioanalytical method development, pharmacokinetic studies, and receptor binding assays.
• Drug Discovery: Serves as a crucial precursor for structure-activity relationship (SAR) studies aimed at improving peptide stability and efficacy.
• Academic Research: Employed in biochemical and pharmacological research to study somatostatin receptor subtypes and signaling pathways.
• Quality Control: Acts as a system suitability standard and impurity marker in the HPLC analysis of octreotide-based drug substances and products.

Basic Information

Product Name	n-Acetyl-Phe-Octreotide
CAS No.	83795-61-3
Molecular Formula	C58H78N12O12S2
Molecular Weight	1199.44 g/mol
Synonyms	Ac-Phe-c[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol; N-Acetyl-Phenylalanine-Octreotide; Acetyl-Phe-Octreotide; Octreotide, N-acetyl-Phe-; [Ac-Phe1,D-Phe2,Cys3,Tyr5,D-Trp8,Lys9,Thr10,Cys14]-Somatostatin-14; SMS 201-995 analog; Somatostatin Octapeptide Analog
EINECS	Contact for details

Quality Control

Our n-Acetyl-Phe-Octreotide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity assessment. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetic Acid Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.