Description

H-Gly-Pro-Hyp-OH is a synthetic tripeptide derivative of collagen, consisting of glycine, proline, and hydroxyproline. This compound is a crucial building block and model system for studying collagen structure, stability, and biosynthesis in biomedical research. It serves as a high-purity biochemical reagent for pharmaceutical R&D, cosmetic science, and advanced material studies focused on tissue engineering and wound healing applications.

Application

• Biomedical Research: Used as a standard and substrate in studies of collagen metabolism, enzyme kinetics (e.g., prolyl hydroxylase), and peptide stability.
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the development of drugs targeting fibrosis, wound healing, and connective tissue disorders.
• Cosmetic Science: Employed in R&D for anti-aging and skin-repair formulations to study collagen synthesis and peptide absorption.
• Tissue Engineering: Acts as a biochemical cue or component in scaffolds designed to promote cell adhesion and collagen deposition.
• Biochemical Reagent: Utilized as a high-purity standard in analytical chromatography (HPLC, LC-MS) for method development and quality control.
• Nutritional Science: Investigated for its role in collagen supplementation and bioavailability studies.

Basic Information

Product Name	H-Gly-Pro-Hyp-OH
CAS No.	2239-67-0
Molecular Formula	C13H21N3O6
Molecular Weight	315.32 g/mol
Synonyms	Glycyl-L-prolyl-4-hydroxy-L-proline; Gly-Pro-Hyp; GPO; Collagen Tripeptide; (2S,4R)-1-[(2S)-2-[(2-Aminoacetyl)amino]-5-oxopyrrolidin-1-yl]-4-hydroxypyrrolidine-2-carboxylic acid; L-Glycyl-L-prolyl-trans-4-hydroxy-L-proline; H-Gly-Pro-trans-4-Hyp-OH; GP-Hyp
EINECS	Contact for details

Quality Control

Our H-Gly-Pro-Hyp-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via mass spectrometry and IR. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.