Description

Hyaluronidase is a hydrolytic enzyme that specifically breaks down hyaluronic acid, a key component of the extracellular matrix. This action is critical for increasing tissue permeability and facilitating the diffusion and absorption of other injected substances. It is an essential pharmaceutical ingredient primarily utilized by manufacturers in the biopharmaceutical, cosmetic, and research sectors for applications requiring enhanced drug delivery and tissue modulation.

Application

• Pharmaceutical Adjuvant: Used to enhance the dispersion and absorption of locally injected drugs (e.g., anesthetics, antibiotics, and contrast media) by reducing tissue barrier resistance.
• Ophthalmic Surgery: Employed to create a space for surgical procedures by hydrolyzing the vitreous humor and facilitating the administration of intraocular medications.
• Dermatology & Aesthetics: Acts as an antidote to correct complications from hyaluronic acid-based dermal fillers by rapidly degrading the filler material.
• Subcutaneous Fluid Administration (Hypodermoclysis): Increases the rate of absorption for large volumes of fluids administered subcutaneously, particularly in pediatric and geriatric care.
• Diagnostic Agent Enhancement: Improves the diffusion of radiographic contrast agents in subcutaneous urography and other imaging techniques.
• Research & Cell Biology: A vital tool in laboratory research for degrading hyaluronan in tissue samples, cell cultures, and studies of the extracellular matrix.
• Veterinary Medicine: Applied to improve the diffusion of injectable therapeutics and fluids in animal healthcare.

Basic Information

Product Name	Hyaluronidase
CAS No.	37326-33-3
Molecular Formula	Protein / Enzyme
Molecular Weight	~61,000 Da (Approximate, varies by source and isoform)
Synonyms	Hyaluronoglucosaminidase; Hyaluronate 4-glycanohydrolase; Spreading factor; Alidase; Wydase; Hyazyme; Hyalase; Ronidase; Amphadase; Hylase "Dessau"; Hyaluronidase BP; Hyaluronidase USP
EINECS	253-476-7

Quality Control

Our Hyaluronidase is produced and tested under strict quality management systems to ensure it meets the high standards required for pharmaceutical and research use. Each batch is subjected to rigorous analytical testing for potency (IU/mg), purity, protein content, and specific activity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing compliance with relevant pharmacopeial monographs such as USP and BP.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be kept in a cool, dry place. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or almost white, amorphous powder
Identification (IR)	Conforms
Assay (Enzymatic Activity)	≥ 300 IU/mg (or as per customer grade requirement)
Protein Content (Biuret)	≥ 90%
pH (in solution)	6.0 - 7.5
Loss on Drying	≤ 5.0%
Bacterial Endotoxins	< 1.0 IU/IU of Hyaluronidase
Sterility (if supplied sterile)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.