Description

(2S,2'S)-[[(2R, 5R)-1-[3,5-difluoro-4-(4-(4- fluorophenyl)-1-piperidinyl)phenyl]-2,5-pyrrolidinediyl]bis[6-fluoro-2-(2S)-2-pyrrolidinyl 1H-benzimidzol e-2,5-diyl)]bis(1-pyrrolidinecarboxylic acid, 1,1'-bis(1,1'-dimethylethyl)ester is a complex, high-purity chiral intermediate of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring multiple stereocenters and fluorinated benzimidazole motifs, makes it a critical building block for the synthesis of novel therapeutic agents. This compound is primarily targeted at R&D and process chemistry teams within the pharmaceutical and biotechnology sectors, where it is used to develop new drug candidates, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for targeted therapies.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of complex linker-warhead systems due to its defined stereochemistry and functional groups.
• Kinase Inhibitor Research: Acts as a core structural component in the development of next-generation, high-selectivity kinase inhibitors.
• Preclinical Candidate Synthesis: Employed in medicinal chemistry for the scale-up and optimization of lead compounds during drug discovery.
• Process Chemistry & Route Scouting: Utilized to develop and validate efficient, scalable synthetic routes for complex molecules under GMP-like conditions.
• Chemical Biology Probes: Incorporated into molecular tools for studying protein function and cellular pathways.

Basic Information

Product Name	(2S,2'S)-[[(2R, 5R)-1-[3,5-difluoro-4-(4-(4- fluorophenyl)-1-piperidinyl)phenyl]-2,5-pyrrolidinediyl]bis[6-fluoro-2-(2S)-2-pyrrolidinyl 1H-benzimidzol e-2,5-diyl)]bis(1-pyrrolidinecarboxylic acid, 1,1'-bis(1,1'-dimethylethyl)ester
CAS No.	1890114-11-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2S,2'S)-1,1'-di-tert-butyl 2,2'-(2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(6-fluoro-1-((S)-pyrrolidin-2-yl)-1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate; tert-Butyl (2S)-2-[5-[(2R,5R)-1-[3,5-difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]phenyl]-2,5-pyrrolidinediyl]-6-fluoro-1-[(2S)-2-pyrrolidinyl]-1H-benzimidazol-2-yl]-1-pyrrolidinecarboxylate 1,1'-bis(1,1-dimethylethyl) ester; CAS 1890114-11-0; Advanced Pharmaceutical Intermediate; Chiral Fluorinated Benzimidazole Derivative; PROTAC Linker Intermediate.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and traceability. Certificates of Analysis (COA) are provided with each shipment, detailing critical quality attributes such as chiral purity, chemical purity, and impurity profiles. Our quality protocols are designed to support regulatory filings, with testing performed using validated methods including HPLC, chiral HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Maximum Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.