Description

Biotinyl-Calcitonin (Salmon I), Biotinyl-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2, (Disulfide bond) is a high-purity, biotinylated derivative of the salmon calcitonin peptide, designed for advanced research and diagnostic applications. This modified peptide is a critical reagent for detection, purification, and imaging studies due to its strong and specific affinity for avidin and streptavidin. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic kit manufacturers focused on bone metabolism, calcium regulation, and targeted drug delivery systems. The compound offers a reliable and sensitive tool for developing novel assays and therapeutic conjugates.

Application

• Bioconjugation & Probe Development: Acts as a versatile linker for attaching calcitonin to avidin/streptavidin-coated surfaces, beads, or fluorophores for detection systems.
• Targeted Drug Delivery Research: Serves as a model compound in preclinical studies for developing bone-targeted therapeutic agents and imaging probes.
• Diagnostic Assay Manufacturing: Used as a key component in the development of immunoassays (ELISA, Western Blot) and biosensors for calcitonin and related biomarkers.
• Receptor Binding & Signal Transduction Studies: Facilitates the study of calcitonin receptor interactions, internalization pathways, and downstream cellular signaling events.
• Affinity Purification: Enables the isolation and purification of calcitonin-binding proteins or antibodies using avidin-biotin chromatography.
• Cell Imaging & Microscopy: Employed in fluorescence-activated cell sorting (FACS) and immunohistochemistry (IHC) for visualizing receptor distribution and cellular uptake.

Basic Information

Item	Details
Product Name	Biotinyl-Calcitonin (Salmon I)
CAS No.	1816258-28-2
Molecular Formula	C₁₆₀H₂₄₆N₄₈O₄₈S₃
Molecular Weight	3607.1 g/mol (monoisotopic)
Synonyms	Biotin-Salmon Calcitonin; Biotinylated sCT; Biotin-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond); Biotinyl-Calcitonin (1-32), salmon, biotinylated; Biotin-SCT; Calcitonin (salmon), biotin conjugate
EINECS	Contact for details

Quality Control

Our Biotinyl-Calcitonin (Salmon I) is manufactured under strict quality systems suitable for research and diagnostic use. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing specifications such as purity by HPLC, peptide content, and biotin incorporation ratio. We adhere to high standards of quality control to ensure reliable performance in sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under inert atmosphere or desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Biotin Incorporation	≥ 1.0 mol biotin / mol peptide
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.