Description

Methyl (33R,35S,91R,92R,5S,Z)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylate is a highly complex, stereochemically defined macrocyclic compound designed for advanced pharmaceutical research and development. This molecule serves as a critical synthetic intermediate or a potential pharmacophore in the discovery of novel therapeutic agents, particularly in oncology and anti-infective fields. It is primarily utilized by pharmaceutical R&D organizations, contract research organizations (CROs), and fine chemical suppliers engaged in cutting-edge drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used as a core scaffold or precursor for screening and developing new chemical entities (NCEs) with targeted biological activity.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies due to its defined stereochemistry and functional groups.
• Process Chemistry Development: Serves as a reference standard or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Utilized in university and institutional labs for studying novel organic reactions and macrocyclic chemistry.
• Bioconjugation Probe Development: Potential use in creating targeted drug conjugates or diagnostic agents, leveraging its reactive alkyne moiety.

Basic Information

Product Name	Methyl (33R,35S,91R,92R,5S,Z)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylate
CAS No.	1425038-23-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(33R,35S,91R,92R,5S,Z)-5-(tert-Butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-12-yne-35-carboxylic acid methyl ester; CAS 1425038-23-8; Macrocyclic quinoxaline-pyrrolidine hybrid; Complex polyheterocyclic ester; Advanced pharmaceutical intermediate 1425038-23-8.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and key impurity profiles are available upon request. We adhere to quality management systems suitable for supporting research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.