Description

(2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol is a sophisticated nucleoside analogue derivative, engineered for high-affinity binding and modulation of specific biological targets. This compound matters as a critical advanced pharmaceutical intermediate or research-grade reference standard in the development of next-generation therapeutics. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oncology, virology, and metabolic disease pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral or anticancer drug candidates.
• Biochemical Research: Used as a high-purity reference standard in enzymatic assays and target validation studies.
• Proteomics & Molecular Biology: Employed in the study of nucleotide-protein interactions and signal transduction pathways.
• Preclinical Development: Serves as a starting material for the preparation of metabolites or labeled analogs for ADME/Tox studies.
• Chemical Biology Probe: Utilized to investigate the function of specific enzymes or receptors in cellular models.
• Process Chemistry: Acts as a critical intermediate in the scale-up and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	(2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
CAS No.	1380288-87-8
Molecular Formula	C31H44N8O4
Molecular Weight	592.74 g/mol
Synonyms	9H-Purin-6-amine, 9-[(2R,3R,4S,5R)-5-[[[(1r,3S)-3-[2-[5-(1,1-Dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]methyl]-3,4-dihydroxyoxolan-2-yl]-; Modified Nucleoside Derivative; Tert-Butyl Benzimidazole Nucleoside Analog; Cyclobutyl-Modified Adenosine Derivative; Advanced Pharmaceutical Intermediate 1380288-87-8; Research Biochemical 1380288-87-8
EINECS	Contact for details

Quality Control

Our (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity and chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.