Description

Fluorodeoxyuridylate CAS NO 134-46-3 is a fluorinated nucleotide analog, a key intermediate in biochemical research and pharmaceutical development. Its primary significance lies in its role as an active metabolite of the chemotherapeutic agent 5-Fluorouracil (5-FU), making it a critical compound for studying mechanisms of action and resistance in cancer therapy. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on oncology drug development, metabolic pathway analysis, and nucleotide biochemistry.

Application

• Oncology Research: Critical for studying the mechanism of action of 5-Fluorouracil (5-FU), particularly its inhibition of thymidylate synthase (TS), a key enzyme in DNA synthesis.
• Biochemical Pathway Analysis: Used as a standard or probe in enzymatic assays to investigate pyrimidine metabolism and nucleotide salvage pathways.
• Pharmaceutical Intermediate: Serves as a reference standard and a high-purity building block in the development and quality control of antimetabolite chemotherapeutics.
• Cell Biology Studies: Employed in research to understand cell cycle arrest and apoptosis induced by fluoropyrimidine drugs.
• Enzyme Inhibition Studies: A vital tool for in vitro screening and characterizing novel inhibitors targeting nucleotide-metabolizing enzymes.
• Academic Research: Used in university and institutional labs for fundamental research in medicinal chemistry and molecular biology.

Basic Information

Product Name	Fluorodeoxyuridylate
CAS No.	134-46-3
Molecular Formula	C10H12FN2O8P
Molecular Weight	338.19 g/mol
Synonyms	5-Fluoro-2'-deoxyuridine 5'-monophosphate; FdUMP; 5-Fluorodeoxyuridine monophosphate; 5-Fluoro-2'-deoxyuridylate; 5-Fluoro-dUMP; Fluorodeoxyuridine monophosphate; 5-FdUMP; 2'-Deoxy-5-fluorouridine 5'-monophosphate
EINECS	205-143-8

Quality Control

Our Fluorodeoxyuridylate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support our customers' compliance needs in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity. Allow the container to reach room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.