Description

(6R,7S)-7-[[(2R)-2-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin derivative. It is a critical building block in the synthesis of modern, broad-spectrum β-lactam antibiotics, offering a pathway to enhanced drug efficacy and stability. This compound is essential for research institutions and manufacturers in the pharmaceutical industry focused on developing and producing next-generation antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key intermediate in the production of advanced-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of novel antibacterial compounds with improved pharmacokinetic profiles.
• Process Chemistry & Scale-Up: Serves as a critical reference standard and starting material for optimizing manufacturing routes for cephalosporin-based drugs.
• Antibacterial Agent Formulation: Employed in the development of injectable and oral dosage forms targeting resistant bacterial strains.

Basic Information

Product Name	(6R,7S)-7-[[(2R)-2-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
CAS No.	1315481-36-7
Molecular Formula	C27H28N8O8S2
Molecular Weight	656.69 g/mol
Synonyms	Ceftolozane Impurity; Ceftolozane Related Compound; (6R,7S)-3-(((1-Methyl-1H-tetrazol-5-yl)thio)methyl)-7-((R)-2-((4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; FR 264205 Intermediate; 7β-[(R)-2-[4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino-2-(4-hydroxyphenyl)acetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (6R,7S)-7-[[(2R)-2-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.