Description

Abz-Amyloid β/A4 Protein Precursor770 (708-715)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide trifluoroacetate salt Abz-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(Dnp)-D-Arg-D-Arg-D-Arg-NH2 trifluoroacetate salt is a specialized, high-purity synthetic peptide substrate designed for advanced biochemical research. This compound is critical for studying the enzymatic activity and inhibition of proteases involved in neurodegenerative pathways, particularly those related to amyloid precursor protein (APP) processing. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic development focused on Alzheimer's disease and related disorders.

Application

• Protease Activity Assays: Primary substrate for fluorometric and colorimetric assays to measure the activity of β-secretase (BACE) and other relevant proteases.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential therapeutic inhibitors for neurodegenerative diseases.
• Enzyme Kinetics Studies: Enables detailed kinetic analysis (Km, Vmax, Ki) of target enzymes to understand substrate specificity and inhibitor potency.
• Biochemical Research: Serves as a key reagent in fundamental research exploring the proteolytic cleavage mechanisms of the amyloid precursor protein.
• Diagnostic Development: Utilized in the development and validation of in vitro diagnostic (IVD) tests for enzymatic biomarkers.
• Quality Control for Inhibitors: Acts as a reference standard for the quality control and potency testing of candidate drug compounds.

Basic Information

Product Name	Abz-Amyloid β/A4 Protein Precursor770 (708-715)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide trifluoroacetate salt Abz-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(Dnp)-D-Arg-D-Arg-D-Arg-NH2 trifluoroacetate salt
CAS No.	1182723-43-8
Molecular Formula	C96H152N38O22 • 2C2HF3O2
Molecular Weight	~2290.4 g/mol (Free base)
Synonyms	APP770 (708-715) Fluorogenic Substrate; Abz-GGVVIATVK(Dnp)-dRRR-NH2 TFA salt; β-Secretase Substrate, Fluorogenic; BACE-1 Substrate (APP770 sequence); Amyloid Precursor Protein Secretase Substrate; (Abz)Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-D-Arg-D-Arg-D-Arg-NH2 (alternative sequence representation); AβPP770(708-715) peptide
EINECS	Contact for details

Quality Control

This peptide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using HPLC, MS, and amino acid analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, water content, and TFA content is provided with every shipment, supporting compliance with GLP and research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 8.0%
Solubility	Soluble in DMSO, aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.