Description

(R)-N-(2,6-Bis(4-methoxyphenyl)-4-oxido-7a,8,9,10,11,11a,12,13,14,15-decahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,1,1-trifluoromethanesulfonamide is a sophisticated chiral organophosphorus compound featuring a trifluoromethanesulfonamide (triflyl) group. This molecule is of significant interest as a highly specialized intermediate or ligand in advanced synthetic chemistry, particularly for applications requiring precise stereochemical control. It is primarily sought after by pharmaceutical research and development organizations and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or antiviral targets.
• Asymmetric Catalysis: Potential use as a chiral ligand or precursor for ligands in transition metal-catalyzed asymmetric reactions, such as hydrogenations or cross-couplings.
• Chemical Biology Probe: Utilized in research to study enzyme mechanisms or protein interactions where a phosphorous-based stereogenic center is critical.
• Advanced Material Research: Investigation as a component in chiral polymers or frameworks for specialized separation technologies or sensors.
• Process Chemistry Development: Serves as a critical intermediate in the development and scale-up of synthetic routes for complex molecules under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	(R)-N-(2,6-Bis(4-methoxyphenyl)-4-oxido-7a,8,9,10,11,11a,12,13,14,15-decahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,1,1-trifluoromethanesulfonamide
CAS No.	1071853-99-0
Molecular Formula	C36H33F3NO7PS
Molecular Weight	711.68 g/mol
Synonyms	(R)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin Triflamide Derivative; (R)-4-[(Trifluoromethyl)sulfonyl]amino]-2,6-bis(4-methoxyphenyl)-4-oxido-decahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine; (R)-Triflyl-protected BINOL-Derived Phosphoric Amide; (R)-H8-BINOL-Derived Triflamide Phosphonate; (R)-N-Triflyl-2,6-bis(4-methoxyphenyl)-4-oxido-7a,8,9,10,11,11a,12,13,14,15-decahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for research and development. Identity and purity are confirmed via advanced analytical techniques including HPLC, NMR (1H, 13C, 31P), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity, and residual solvent levels is provided with each shipment to support your regulatory and process development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and desiccated for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.