Description

Triphenylphosphine Hydrobromide is a versatile and highly reactive organophosphorus compound, primarily valued as a stable and convenient source of the triphenylphosphine ligand and bromide anion. Its significance lies in its role as a key reagent for facilitating various organic transformations, particularly in the synthesis of complex pharmaceutical intermediates and fine chemicals. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable reagent for coupling reactions, deoxygenations, and as a precursor to Wittig reagents.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent in Mitsunobu reactions for the inversion of stereocenters and formation of esters and ethers.
• Catalyst & Ligand Precursor: Serves as a starting material for generating various phosphine-based catalysts used in cross-coupling reactions (e.g., Suzuki, Heck).
• Wittig Reaction Reagent: Used in the preparation of ylides for the stereoselective synthesis of alkenes from carbonyl compounds.
• Deoxygenation Agent: Employed in the reduction of sulfoxides to sulfides and other deoxygenation processes.
• Polymer Chemistry: Acts as a chain transfer agent or catalyst component in specific polymerization processes.
• Organic Synthesis Research: A fundamental tool in academic and industrial R&D for constructing complex molecular architectures.

Basic Information

Product Name	Triphenylphosphine Hydrobromide
CAS No.	6399-81-1
Molecular Formula	C18H18BrP
Molecular Weight	345.22 g/mol
Synonyms	Triphenylphosphonium Bromide; Phosphonium, triphenyl-, bromide; Hydrobromotriphenylphosphorane; TPP·HBr; Triphenylphosphane Hydrobromide; (Triphenylphosphoranylidene)methanaminium Bromide (in specific contexts); PPh3·HBr
EINECS	229-035-5

Quality Control

Our Triphenylphosphine Hydrobromide is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	192 - 198 °C
Loss on Drying	≤ 1.0 %
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.