Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-(4-nitrophenyl)-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)- is a high-value, stereochemically defined synthetic intermediate with a complex molecular architecture. This compound matters for its role as a key building block in advanced pharmaceutical research, particularly in the synthesis of novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on complex, target-oriented organic syntheses.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or requiring sophisticated chiral centers.
• Advanced Organic Synthesis: Serves as a versatile building block for constructing complex heterocyclic frameworks and fused ring systems in academic and industrial research.
• Process Chemistry Development: Used in route scouting and optimization studies for the scalable production of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by providing a functionalized, protected core structure for analog generation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-(4-nitrophenyl)-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-
CAS No.	188744-94-7
Molecular Formula	C26H39NO7Si
Molecular Weight	505.68 g/mol
Synonyms	(3aR,4R,6S,6aS)-4-((tert-Butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-(4-nitrophenyl)tetrahydro-4H-furo[3,4-d][1,3]dioxole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aR,4R,6S,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-(4-nitrophenyl)tetrahydro-4H-furo[3,4-d][1,3]dioxole-5-carboxylate; 5H-1,3-Dioxolo[4,5-c]pyrrole-5-carboxylic acid derivative; TBDMS-protected nitroaryl tetrahydrofurodioxole carboxylate; Advanced pharmaceutical intermediate 188744-94-7; CAS 188744-94-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.