Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyl-6-4-(di-2-propenylamino)phenyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)- is a sophisticated, high-purity chiral intermediate featuring a complex molecular architecture with multiple protective groups. This compound is critical for enabling precise synthetic pathways in advanced pharmaceutical research and development. It is primarily utilized by process chemists and R&D teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of target molecules, leveraging its tert-butyldimethylsilyl (TBDMS) and tert-butyl ester protective groups.
• Asymmetric Synthesis: Serves as a precursor in stereoselective reactions to construct molecules with specific three-dimensional configurations required for biological activity.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chemical purity and stereochemical fidelity.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyl-6-4-(di-2-propenylamino)phenyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-
CAS No.	188744-90-3
Molecular Formula	C30H46N2O5Si
Molecular Weight	542.79 g/mol
Synonyms	(3aR,4R,6S,6aS)-4-[[(tert-Butyldimethylsilyl)oxy]methyl]-6-[4-(diallylamino)phenyl]tetrahydro-2,2-dimethyl-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aR,4R,6S,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-6-(4-(diallylamino)phenyl)-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; 5H-[1,3]Dioxolo[4,5-c]pyrrole-5-carboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl-6-[4-(di-2-propen-1-ylamino)phenyl]tetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-; TBDMS-protected chiral dioxolopyrrole intermediate.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We employ state-of-the-art analytical techniques, including chiral HPLC and NMR spectroscopy, to guarantee high stereochemical purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your R&D or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.