Description

[9a,9'a(2H,2'H)-Binaphtho[2,3-b]furan]-2,2'-dione, 4,4',4a,4'a,5,5',6,6',7,7',8,8',8a,8'a,9,9'-hexadecahydro-3,3',8a,8'a-tetramethyl-5,5'-bis(methylene)-, (4aR,4'aR,8aS,8'aS,9aR,9'aR)- is a complex, stereochemically defined binaphthofuran derivative that serves as a highly valuable chiral building block for advanced organic synthesis. Its intricate fused-ring structure and defined stereochemistry make it a critical intermediate for constructing sophisticated molecular architectures. This compound is primarily needed by pharmaceutical R&D and fine chemical sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and anti-cancer therapeutics.
• Asymmetric Catalysis Ligand Synthesis: Used to construct sophisticated chiral ligands for transition metal catalysts, enabling highly enantioselective transformations.
• Advanced Material Research: Serves as a core unit for developing novel organic electronic materials, liquid crystals, or polymers with specific optical properties.
• Natural Product Synthesis: Acts as a synthetic equivalent for complex polycyclic frameworks found in natural products, aiding in total synthesis efforts.
• Chemical Biology Probes: Utilized to create structurally unique probes for studying enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	[9a,9'a(2H,2'H)-Binaphtho[2,3-b]furan]-2,2'-dione, 4,4',4a,4'a,5,5',6,6',7,7',8,8',8a,8'a,9,9'-hexadecahydro-3,3',8a,8'a-tetramethyl-5,5'-bis(methylene)-, (4aR,4'aR,8aS,8'aS,9aR,9'aR)-
CAS No.	182426-37-5
Molecular Formula	C32H38O4
Molecular Weight	486.65 g/mol
Synonyms	(4aR,4'aR,8aS,8'aS,9aR,9'aR)-4,4',4a,4'a,5,5',6,6',7,7',8,8',8a,8'a,9,9'-Hexadecahydro-3,3',8a,8'a-tetramethyl-5,5'-bis(methylene)-[9a,9'a(2H,2'H)-binaphtho[2,3-b]furan]-2,2'-dione; Hexadecahydro-binaphthofurandione derivative; Chiral Binaphthofuran Dione; (all-R)-Isomer of C32H38O4; Tetramethyl-bis(methylene)-hexadecahydrobinaphthofurandione
EINECS	Contact for details

Quality Control

Our high-purity chiral intermediates are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral HPLC to confirm enantiomeric excess and NMR for structural verification. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are provided with every shipment to ensure reproducible results in your critical R&D and process development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.