Description

(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyimino-acetyl]amino]- 8-oxo-3-(2H-triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-azabicyclo[4. 2.0]oct-2-ene-2-carboxylic acid hydrate hydrochloride is a key advanced pharmaceutical intermediate, specifically a cephalosporin derivative. This compound is critical for the synthesis of next-generation, broad-spectrum antibiotics, offering a foundation for developing formulations with enhanced efficacy. It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in active pharmaceutical ingredients (APIs) for anti-infective therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of advanced cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for research and development of new antibacterial agents.
• Antibiotic Synthesis: Used in the chemical production of potent, broad-spectrum antibiotics targeting resistant bacterial strains.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of β-lactam compounds.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Product Name	(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyimino-acetyl]amino]- 8-oxo-3-(2H-triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-azabicyclo[4. 2.0]oct-2-ene-2-carboxylic acid hydrate hydrochloride
CAS No.	154776-45-1
Molecular Formula	C15H16N8O6S3 • HCl • xH2O
Molecular Weight	Contact for details
Synonyms	Ceftriaxone Impurity H; Ceftriaxone Related Compound H; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]thio-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride Hydrate; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-8-oxo-3-[[(1H-1,2,3-triazol-4-yl)thio]methyl]thio-, hydrochloride, hydrate, (6R,7R)-; Ceftriaxone EP Impurity H; Ceftriaxone Hydrochloride Impurity H
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.