Description

[5R-(5alpha,5abeta,8aalpha,9beta)]-9-[2-[N-[2-(Dimethylamino)ethyl]-N-methylamino]ethyl]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-one is a complex, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its intricate polycyclic structure, featuring a fused furo-naphtho-dioxole core with a dimethylaminoethyl side chain, makes it a valuable precursor for the synthesis of novel bioactive compounds. This product is primarily targeted at pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of potential new drug candidates, particularly in oncology and CNS therapeutic areas.
• Biochemical Research: Used as a reference standard or a probe compound in pharmacological and biochemical studies to investigate enzyme interactions or receptor binding.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes in process chemistry for Active Pharmaceutical Ingredient (API) development.
• Academic Research: Utilized in university and institutional laboratories for synthetic organic chemistry projects and the exploration of new chemical entities.
• Custom Synthesis: Starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client-specific projects.

Basic Information

Item	Details
Product Name	[5R-(5alpha,5abeta,8aalpha,9beta)]-9-[2-[N-[2-(Dimethylamino)ethyl]-N-methylamino]ethyl]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-one
CAS No.	148262-19-5
Molecular Formula	C31H38N2O8
Molecular Weight	566.65 g/mol
Synonyms	Paclitaxel impurity; Taxol derivative; 10-Deacetylbaccatin III derivative; Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-one derivative; (2'R,3S,4S,5R,8S,9S,10S,13S)-9-[2-(Dimethylamino)ethyl]-13-[(2R,3R)-3-(4-hydroxy-3,5-dimethoxyphenyl)-2-(hydroxymethyl)oxiran-2-yl]-5,10-dihydroxy-3,11-dioxo-4,8,13-trioxatetracyclo[10.7.1.0²,¹⁰.0⁵,⁹]icosa-1(19),6,15,17-tetraen-12-yl acetate (related structure); Complex taxane analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [5R-(5alpha,5abeta,8aalpha,9beta)]-9-[2-[N-[2-(Dimethylamino)ethyl]-N-methylamino]ethyl]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-one is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.