Description

(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(1-methyl-2,3,4,5-tetrahydropyrrol-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is a high-purity pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. It is a critical building block for the synthesis of advanced third-generation cephalosporin antibiotics, offering a key structural moiety for broad-spectrum antibacterial activity. This compound is essential for manufacturers in the pharmaceutical industry focused on developing and producing potent, modern antibiotic APIs.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key intermediate in the production of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Serves as a crucial starting material or intermediate in medicinal chemistry for developing new antibacterial agents.
• Generic Drug Manufacturing: Used in the cost-effective and reliable production of generic versions of established cephalosporin drugs.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs specializing in antibiotic production for global pharmaceutical clients.
• Antibiotic Formulation: Integral to the synthesis of final drug substances that are formulated into injectable or oral dosage forms.

Basic Information

Product Name	(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(1-methyl-2,3,4,5-tetrahydropyrrol-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.	143892-90-4
Molecular Formula	C₂₁H₂₆N₆O₆S₂
Molecular Weight	522.60 g/mol
Synonyms	7-ACA Derivative (Aminothiazolyl Methoxyimino Pyrrolidinium); 7β-[2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate; Cephalosporin C-7 Side Chain Intermediate; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; CETB Nucleus Derivative; Antibiotic Intermediate 143892-90-4
EINECS	Contact for details

Quality Control

Our (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(1-methyl-2,3,4,5-tetrahydropyrrol-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is manufactured under strict quality systems suitable for pharmaceutical applications. All batches undergo rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with stringent internal specifications. Certificates of Analysis (COA) documenting identity, purity, and related substances are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.