Description

(S,S)-ANDEN-Phenyl Trost Ligand, also known as (+)-(11S,12S)Bis[2′-(diphenylphosphino)benzamido]-9,10-dihydro-9,10-ethanoanthracene, is a highly specialized chiral bisphosphine ligand crucial for enabling enantioselective transformations in organic synthesis. Its value lies in its ability to induce high levels of stereoselectivity in transition metal-catalyzed reactions, particularly palladium-catalyzed asymmetric allylic alkylations, which are fundamental for constructing complex chiral molecules. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing active pharmaceutical ingredients (APIs), advanced intermediates, and other high-value chiral compounds.

Application

• Asymmetric Allylic Alkylation (AAA): A premier ligand for palladium-catalyzed asymmetric allylic substitution reactions, a cornerstone for creating chiral carbon centers.
• Pharmaceutical Intermediate Synthesis: Critical in the research and development of enantiomerically pure drug candidates and active pharmaceutical ingredients (APIs).
• Fine Chemical Production: Used in the synthesis of complex, high-value chiral molecules for agrochemicals, flavors, and fragrances.
• Catalyst Development & Screening: A key component in catalyst libraries for discovering new enantioselective catalytic processes.
• Academic & Industrial R&D: A vital tool for synthetic organic chemists in universities and corporate research laboratories exploring new asymmetric methodologies.

Basic Information

Product Name	(S,S)-ANDEN-Phenyl Trost Ligand
CAS No.	138517-65-4
Molecular Formula	C66H52N2O2P2
Molecular Weight	967.07 g/mol
Synonyms	(+)-(11S,12S)Bis[2′-(diphenylphosphino)benzamido]-9,10-dihydro-9,10-ethanoanthracene; (11S,12S)-N,N′-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide]; (S,S)-ANDEN-Phenyl Trost Ligand; Trost ANDEN-Phenyl Ligand; (S,S)-ANDEN-Phenyl Ligand; (S,S)-Bisphosphine Trost Ligand; (11S,12S)-Ethanoanthracene-Derived Bisphosphine Ligand
EINECS	Contact for details

Quality Control

Our (S,S)-ANDEN-Phenyl Trost Ligand is manufactured under strict quality protocols to ensure high purity and consistent performance for sensitive catalytic applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis to confirm identity, chiral purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade its catalytic performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.