Description

5-Thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-, [6R-[6α,7β(Z)]]- (9CI) is a high-purity pharmaceutical intermediate of significant importance in the synthesis of advanced cephalosporin antibiotics. This compound is valued for its role as a key building block, enabling the production of potent antibacterial agents with a broad spectrum of activity. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation β-lactam antibiotics to combat resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of third and fourth-generation cephalosporin antibiotics.
• Antibacterial Agent Research: Used in medicinal chemistry research for developing new β-lactam compounds with enhanced efficacy.
• Active Pharmaceutical Ingredient (API) Manufacturing: A key raw material in the production chain for finished dosage forms of specific cephalosporin drugs.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale synthesis for commercial antibiotic production.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory testing of related APIs.

Basic Information

Item	Details
Product Name	5-Thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-, [6R-[6α,7β(Z)]]- (9CI)
CAS No.	120962-17-6
Molecular Formula	C19H17N5O7S3
Molecular Weight	523.56 g/mol
Synonyms	7β-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(furoylthio)methyl]-3-cephem-4-carboxylic acid; Cefuroxime Impurity; Cefuroxime Related Compound; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(furan-2-carbonylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefuroxime Acid; Cefuroxime Intermediate; 7-ACA Derivative
EINECS	Contact for details

Quality Control

Our 5-Thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance with cGMP and relevant pharmacopeial guidelines for advanced pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.