Description

(6R,7R)-7-[[(2-Amino-4-thiazolyl)[(Z)-hydroxyimino]acetyl]amino]-8-oxo-3-[(Z)-1-propenyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester is a key advanced pharmaceutical intermediate, specifically a prodrug derivative of a third-generation cephalosporin antibiotic. This compound is critical for enhancing the bioavailability and stability of the active pharmaceutical ingredient (API) in final drug formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of potent, broad-spectrum antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial intermediate in the multi-step synthesis of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in preclinical and clinical research for developing new antibacterial therapies with improved pharmacokinetic profiles.
• Prodrug Formulation: Employed to create ester prodrugs that improve oral absorption of the parent cephalosporin molecule.
• Antibiotic Manufacturing: A vital building block in the commercial-scale GMP production of finished dosage forms (e.g., tablets, capsules, injectables).
• Chemical Reference Standard: Used as a high-purity standard for quality control and analytical method development in pharmaceutical labs.
• Process Chemistry Optimization: Applied in scaling up and optimizing synthetic routes for cost-effective and efficient API production.

Basic Information

Product Name	(6R,7R)-7-[[(2-Amino-4-thiazolyl)[(Z)-hydroxyimino]acetyl]amino]-8-oxo-3-[(Z)-1-propenyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester
CAS No.	107888-51-7
Molecular Formula	C22H27N5O8S2
Molecular Weight	553.61 g/mol
Synonyms	Cefpodoxime Proxetil Intermediate; Cefpodoxime Acid Pivaloyloxymethyl Ester; (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[(Z)-1-propenyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid POM ester; Cefpodoxime Proxetil Key Intermediate; Pivoxil Ester of Cefpodoxime Acid; CS-807 Ester; U-76252E; R-3763
EINECS	Contact for details

Quality Control

Our (6R,7R)-7-[[(2-Amino-4-thiazolyl)[(Z)-hydroxyimino]acetyl]amino]-8-oxo-3-[(Z)-1-propenyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isomeric integrity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided with each batch to support regulatory filings and GMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Isomeric Purity (Z-Isomer)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.