Description

(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetylamino]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid pivaloyloxymethyl ester is a key pharmaceutical intermediate, specifically a prodrug ester of a third-generation cephalosporin antibiotic. This compound is critical for enhancing the bioavailability and stability of the active pharmaceutical ingredient (API) in final drug formulations. It is primarily utilized by pharmaceutical manufacturers and advanced R&D laboratories engaged in the synthesis of potent, broad-spectrum antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: As a crucial prodrug intermediate in the manufacturing of advanced cephalosporin antibiotics.
• Pharmaceutical R&D: For research and development of new antibacterial formulations with improved oral absorption.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for cephalosporin production.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Details
Product Name	(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetylamino]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid pivaloyloxymethyl ester
CAS No.	104712-44-9
Molecular Formula	C22H27N9O7S2
Molecular Weight	593.64 g/mol
Synonyms	Cefpodoxime Pivoxil Intermediate; Cefpodoxime Proxetil Intermediate; (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 1-[[(1,1-Dimethylethoxy)carbonyl]oxy]ethyl Ester, (Z)-2-(O-Methyloxime); Cefpodoxime Acid Pivaloyloxymethyl Ester; RU-51807; CS-807 Intermediate; 1-[[(1,1-Dimethylethoxy)carbonyl]oxy]ethyl (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
EINECS	Contact for details

Quality Control

Our (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetylamino]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid pivaloyloxymethyl ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to stringent specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmaceutical (USP/EP/JP) or custom purity grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.