Description

Sodium (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(E)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a high-purity pharmaceutical intermediate, specifically the sodium salt of a third-generation cephalosporin antibiotic. This compound is critical for ensuring the efficacy and stability of final active pharmaceutical ingredients (APIs) used in advanced antibacterial therapies. It is essential for manufacturers in the pharmaceutical industry engaged in the synthesis of potent, broad-spectrum antibiotics to combat resistant bacterial infections.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary intermediate in the manufacturing of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used as a key reference standard and building block in medicinal chemistry for developing new antibacterial agents.
• Veterinary Medicine Production: Employed in the formulation of injectable antibiotic treatments for veterinary use.
• Sterile Injectable Formulations: Serves as a critical component in the production of lyophilized powders or solutions for parenteral administration.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs specializing in cGMP-compliant synthesis of complex drug substances.
• Quality Control & Analytical Standards: Utilized as a high-purity analytical standard for HPLC, LC-MS, and other pharmacopeial testing methods.

Basic Information

Product Name	Sodium (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(E)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.	104146-53-4
Molecular Formula	C22H20N6NaO7S3
Molecular Weight	607.61 g/mol
Synonyms	Ceftiofur Sodium; Sodium Ceftiofur; Ceftiofur Sodium Salt; (6R,7R)-7-[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-[(E)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; U-64279E; Naxcel (brand name intermediate); Spectramast (brand name intermediate); Excenel (brand name intermediate)
EINECS	Contact for details

Quality Control

Our sodium ceftiofur intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via IR and NMR spectroscopy, to ensure compliance with pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
pH (10% solution)	6.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.