Description

QUINAPRIL RELATED COMPOUND A (50 MG) (ETHYL[3S-[2(R*),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-α-(2-PHENY-LETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE) is a high-purity chemical reference standard, specifically a known impurity and degradation product of the active pharmaceutical ingredient Quinapril. This compound is critical for pharmaceutical research, development, and quality control, enabling precise analytical method validation and impurity profiling. It is primarily used by analytical chemists, quality assurance laboratories, and R&D departments within the global pharmaceutical and contract research organization (CRO) sectors to ensure drug safety, efficacy, and regulatory compliance.

Application

• Pharmaceutical Impurity Profiling and Identification in Quinapril and related drug formulations.
• Analytical Method Development and Validation (HPLC, UPLC, LC-MS) for accurate quantification of related substances.
• Stability-Indicating Method Studies to monitor drug degradation pathways and shelf-life.
• Quality Control (QC) and Quality Assurance (QA) testing of active pharmaceutical ingredients (APIs) and finished dosage forms.
• Regulatory Submission Support, providing characterized reference materials for FDA, EMA, and ICH compliance dossiers.
• Pharmacopeial Testing, serving as a system suitability or reference standard for USP/EP monograph analyses.
• Academic and Clinical Research into the metabolism and pharmacokinetics of ACE inhibitor drugs.

Basic Information

Item	Details
Product Name	QUINAPRIL RELATED COMPOUND A (50 MG)
CAS No.	103733-49-9
Molecular Formula	C25H27N3O5
Molecular Weight	449.50 g/mol
Synonyms	Ethyl (3S)-2-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylate impurity; Quinapril Related Substance A; Quinapril Impurity A; (3S)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine-3-carboxylic acid; 1,3,4,6,11,11a-Hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetic acid ethyl ester; [3S-[2(R*),3a,11abeta]]-Ethyl 1,3,4,6,11,11a-hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetate
EINECS	Contact for details

Quality Control

Our QUINAPRIL RELATED COMPOUND A is manufactured and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation (IR, MS), and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results and confirming compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Desiccate if necessary.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.