Description

4-Hydroxytriamterene is a key pharmaceutical intermediate and metabolite of the diuretic agent triamterene. This compound matters for its critical role in the development and quality control of active pharmaceutical ingredients (APIs) and in advanced pharmacological research. It is primarily needed by manufacturers and R&D teams in the pharmaceutical, biotechnology, and analytical chemistry sectors for synthesis, reference standard applications, and metabolic studies.

Application

• Pharmaceutical intermediate in the synthesis of diuretic APIs.
• Reference standard for quality control and analytical method development (HPLC, LC-MS).
• Metabolite for pharmacokinetic and drug metabolism studies.
• Key starting material (KSM) in advanced organic synthesis.
• Research chemical for investigating renal physiology and electrolyte balance.
• Component in the development of impurity profiles for regulatory filings.

Basic Information

Product Name	4-Hydroxytriamterene
CAS No.	1226-52-4
Molecular Formula	C₁₂H₁₁N₇O
Molecular Weight	269.26 g/mol
Synonyms	4-Hydroxytriamterene; 2,4,7-Triamino-6-(4-hydroxyphenyl)pteridine; 6-(4-Hydroxyphenyl)-2,4,7-pteridinetriamine; Triamterene metabolite; 4'-Hydroxytriamterene; 6-(p-Hydroxyphenyl)-2,4,7-triaminopteridine; Hydroxytriamterene
EINECS	Contact for details

Quality Control

Our 4-Hydroxytriamterene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brownish powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.