Description

10-Hydroxynortriptyline is a significant metabolite of the tricyclic antidepressant nortriptyline, serving as a key reference standard and intermediate in pharmaceutical research and development. Its primary value lies in enabling precise analytical studies for drug metabolism, pharmacokinetics, and bioequivalence testing. This compound is essential for laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors focused on neuropharmacology and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis of nortriptyline and its metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Metabolite Research: Critical for studying the metabolic pathways, pharmacokinetics, and pharmacodynamics of the antidepressant nortriptyline.
• Analytical Method Development: Serves as a key component in developing and validating robust analytical methods for clinical and forensic toxicology.
• Drug Impurity Profiling: Employed to identify and quantify process-related impurities and degradation products in active pharmaceutical ingredient (API) manufacturing.
• Biomedical Research: Utilized in in-vitro and in-vivo studies to investigate the activity and effects of nortriptyline metabolites.

Basic Information

Product Name	10-Hydroxynortriptyline
CAS No.	1156-99-6
Molecular Formula	C18H21NO
Molecular Weight	267.37 g/mol
Synonyms	10-Hydroxynortriptyline; 10-Hydroxy-N-desmethylnortriptyline; 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[a,f]pyrazino[1,2-h]azepin-10-ol; Nortriptyline Metabolite; E-10-hydroxynortriptyline; 10-OH-Nortriptyline; (E)-10-Hydroxynortriptyline
EINECS	Contact for details

Quality Control

Our 10-Hydroxynortriptyline is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.