Description

Oxythiamine Hydrochloride is a synthetic thiamine (vitamin B1) analog that acts as a potent and specific antagonist of the vitamin. This compound is a critical biochemical tool for research into thiamine-dependent metabolic pathways and their associated disorders. It is primarily utilized in life science research, pharmaceutical development, and as a reference standard in analytical chemistry.

Application

• Biochemical Research: Used to induce thiamine deficiency in cell cultures and animal models to study metabolic effects, particularly in carbohydrate metabolism and neurological function.
• Enzyme Inhibition Studies: Serves as a specific inhibitor for thiamine-dependent enzymes like transketolase and pyruvate dehydrogenase, aiding in mechanistic studies.
• Pharmaceutical Reference Standard: Employed as a high-purity certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Metabolic Pathway Analysis: A key reagent for investigating the role of thiamine in diseases such as Wernicke-Korsakoff syndrome, beriberi, and certain mitochondrial disorders.
• Nutritional Science: Used in studies examining thiamine absorption, transport, and antagonism in nutritional models.

Basic Information

Product Name	Oxythiamine Hydrochloride
CAS No.	136-16-3
Molecular Formula	C12H16ClN4O3S
Molecular Weight	340.80 g/mol
Synonyms	Oxythiamine HCl; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride; Thiamine Antagonist; Vitamin B1 Antagonist; 2-Methyl-4-amino-5-pyrimidinylmethylthiazolium Chloride Derivative; Oxyneurine Hydrochloride (obsolete); Thiamine Hydrochloride, Oxy-
EINECS	205-231-7

Quality Control

Our Oxythiamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to prevent degradation from moisture and light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.