Description

[[2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid is a high-purity, complex organophosphorus compound of significant interest in advanced pharmaceutical and biochemical research. Its intricate molecular structure, featuring a thiazolium and pyrimidine core, makes it a valuable intermediate for synthesizing novel bioactive molecules and enzyme cofactor analogs. This compound is primarily sought by research institutions and pharmaceutical developers working on nucleotide metabolism, targeted drug delivery systems, and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of novel drug candidates, particularly those targeting enzymatic pathways involving phosphorylated cofactors.
• Biochemical Research: Used as a precursor or reference standard in studies of nucleotide analogs, enzyme kinetics, and metabolic pathway inhibition.
• Prodrug Development: Serves as a sophisticated building block for creating phosphate-based prodrugs designed for enhanced cellular uptake and targeted release.
• Enzyme Cofactor Analog Synthesis: Employed in the preparation of synthetic analogs of natural coenzymes for mechanistic and structural biology studies.
• Chemical Biology Probes: Utilized to develop labeled or modified probes for investigating protein-ligand interactions and cellular signaling processes.
• Academic & Industrial R&D: A key material for discovery chemistry in both university laboratories and corporate R&D centers focused on life sciences.

Basic Information

Product Name	[[2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
CAS No.	15666-52-1
Molecular Formula	C14H23N4O10P3S
Molecular Weight	532.32 g/mol
Synonyms	Thiamine Triphosphate Analog; TTP Analog; 5-(2-Phosphonooxyethyl)-4-methyl-3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]thiazolium Diphosphate; Thiamine Triphosphate Derivative; Vitamin B1 Triphosphate Derivative; Thiazolium Pyrimidine Phosphonate; 15666-52-1; Thiamine Polyphosphate Intermediate
EINECS	Contact for details

Quality Control

Our [[2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the exacting standards of pharmaceutical R&D and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.